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Related Experiment Video

Updated: Mar 25, 2026

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
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Lipid-based nanoformulations for peptide delivery.

Nada Matougui1, Lukas Boge2, Anne-Claire Groo1

  • 1Inserm U1066 (Micro et Nanomédecines biomimétiques), Angers, France.

International Journal of Pharmaceutics
|February 23, 2016
PubMed
Summary

Lipid nanoformulations (LNFs) offer a promising way to stabilize therapeutic peptides, protecting them from degradation. This review explores formulation strategies and assessment methods for peptide-loaded LNFs.

Keywords:
Drug deliveryLipidsNanoformulationsPeptides

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Area of Science:

  • Nanotechnology
  • Pharmaceutical Sciences
  • Biochemistry

Background:

  • Nanoformulations exhibit unique size-dependent properties, driving significant research interest.
  • Lipid nanoformulations (LNFs) are increasingly recognized for their biocompatibility and versatility.
  • Therapeutic peptides face challenges due to poor physicochemical and biological stability.

Purpose of the Study:

  • To review formulation strategies for incorporating therapeutic peptides into LNFs.
  • To discuss methods for assessing the association efficiency of peptides within LNFs.
  • To outline the advantages and disadvantages of using LNFs for peptide delivery.

Main Methods:

  • Literature review of peptide encapsulation within lipid-based carriers.
  • Analysis of various formulation techniques for peptide-loaded LNFs.
  • Examination of analytical methods for determining peptide association efficiency.

Main Results:

  • LNFs can effectively encapsulate and protect labile therapeutic peptides like insulin, calcitonin, and cyclosporin A.
  • Encapsulation within LNFs mitigates enzymatic degradation of peptides.
  • Various formulation strategies exist, each with specific advantages and drawbacks.

Conclusions:

  • Lipid nanoformulations provide a viable strategy to enhance the stability and delivery of therapeutic peptides.
  • Understanding formulation composition and structure is crucial for LNF performance.
  • LNFs represent a valuable platform for overcoming peptide instability challenges in pharmaceutical development.