Related Experiment Video
Updated: Mar 25, 2026
Salinity-dependent Toxicity Assay of Silver Nanocolloids Using Medaka Eggs
Published on: March 18, 2016
Effects of oral exposure to silver nanoparticles on the sperm of rats
D Lafuente1, T Garcia2, J Blanco1
1Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, "Rovira i Virgili" University, Reus, Catalonia, Spain; Physiology Unit, School of Medicine, IISPV, "Rovira i Virgili" University, Reus, Catalonia, Spain.
Abstract:
It has been demonstrated that exposure to silver nanoparticles (AgNPs) can induce toxicological effects in rodents. In this study, we investigated whether sub-chronic oral exposure to different doses of polyvinil pyrrolidone (PVP)-coated AgNPs (PVP-AgNPs) (50, 100 and 200mg/kg/day) could induce harmful effects on epididymal sperm rat parameters. Sperm motility, viability and morphology were examined. Moreover, a histological evaluation of testis and epididymis was also performed. High doses of PVP-AgNPs showed higher sperm morphology abnormalities, while a progressive, but not significant effect, was observed in other sperm parameters. The current results suggest that oral sub-chronic exposure to PVP-AgNPs induces slight toxicological effects in sperm rat parameters.
