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Updated: Mar 25, 2026
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
Published on: August 14, 2019
Reduced brain connectivity and mental flexibility in mild traumatic brain injury
Elizabeth W Pang1, Benjamin T Dunkley2, Sam M Doesburg3
1Division of Neurology Hospital for Sick Children Toronto Ontario Canada; Program in Neurosciences and Mental Health Sick Kids Research Institute Toronto Ontario Canada; Faculty of Medicine University of Toronto Toronto Ontario Canada.
Objective:
A mild traumatic brain injury (mTBI), or concussion, has known neuropsychological sequelae, and neuroimaging shows disturbed brain connectivity during the resting state. We hypothesized that task-based functional connectivity measures, using magnetoencephalography (MEG), would better link the neurobiological underpinnings of cognitive deficits to specific brain damage.
Methods:
We used a mental flexibility task in the MEG and compared brain connectivity between adults with and without mTBI.
Results:
Affected individuals showed significant reductions in connectivity. When challenged with a more difficult task, these individuals were not able to "boost" their connectivity, and as such, showed deterioration in performance.
Interpretation:
We discuss these findings in the context of limitations in cognitive reserve as a consequence of a mTBI.
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