[Effect of calcitonin on insulin and glucagon secretion by the pancreas]

A study was made of the effect of pig calcitonin (CT) on the levels of insulin and glucagon, glucose stimulated insulin secretion and glucagon secretion in insulin hypoglycemia in rats. Disorder of glucose tolerance after administration of CT at a dose of 1 U per 100 g of body mass was established. CT administration did not influence the level of insulin and inhibited its secretion in GTT. CT resulted in a considerable decrease in the basal level of glucagon and an increase in its secretion in insulin hypoglycemia. CT could be involved in neuroendocrine regulation of carbohydrate metabolism.