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Raised Intraocular Pressure in Nonjuvenile Idiopathic Arthritis-Uveitis Children: Risk Factors and Effect on Retinal

Norshamsiah Md Din1, Oren Tomkins-Netzer, Lazha Talat

  • 1*UCL Institute of Ophthalmology †Moorfields Eye Hospital §Faculty of Medicine, Imperial College London, Hammersmith Hospital, London ∥Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK ‡Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Journal of Glaucoma
|February 23, 2016
PubMed

Insights

Children with chronic uveitis face higher risks of elevated intraocular pressure (IOP) and glaucoma. Inferior retinal nerve fiber layer (RNFL) thinning may indicate glaucomatous changes in these children.

Area of Science:

  • Ophthalmology
  • Pediatric Rheumatology
  • Glaucoma Research

Background:

  • Nonjuvenile idiopathic arthritis-associated uveitis can lead to serious ocular complications.
  • Intraocular pressure (IOP) elevation and glaucoma are significant concerns in pediatric uveitis.
  • Understanding risk factors is crucial for early detection and management.

Purpose of the Study:

  • To identify risk factors for elevated intraocular pressure (IOP) and glaucoma in children with nonjuvenile idiopathic arthritis-related uveitis.
  • To assess IOP-related changes in retinal nerve fiber layer (RNFL) thickness in this patient group.

Main Methods:

  • Retrospective analysis of clinical data from 103 children (206 eyes) with uveitis treated at a tertiary referral clinic.
  • Eyes were categorized into normal, normotensive uveitis (NU), hypertensive uveitis (HU), and glaucomatous uveitis (GU).
  • Risk factors for elevated IOP, glaucoma, and steroid response (SR) were evaluated; RNFL thickness was compared across groups.

Main Results:

  • Elevated IOP occurred in 37.9% of uveitic eyes; steroid response (SR) in 35.1%.
  • Chronic uveitis was a significant risk factor for elevated IOP (OR=9.28), glaucoma, and SR (OR=8.4).
  • Significant inferior RNFL thinning was observed in glaucomatous uveitis (GU) eyes compared to normotensive uveitis (NU) eyes (P=0.043).

Conclusions:

  • Children with chronic uveitis have a significantly higher risk of developing elevated IOP and glaucoma.
  • Inferior RNFL quadrant thinning may serve as an indicator of glaucomatous changes in pediatric uveitis patients with elevated IOP.
Abstract

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