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Progress and prospects for L2-based human papillomavirus vaccines
Rosie T Jiang1, Christina Schellenbacher2, Bryce Chackerian3
1a Department of Pathology , The Johns Hopkins University , Baltimore , MD , USA.
Expert Review of Vaccines
|February 23, 2016
Summary
Human papillomavirus (HPV) vaccines prevent infections but don't cover skin types or treat existing ones. New vaccines targeting the L2 antigen show promise for broader protection and therapeutic applications.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Human papillomavirus (HPV) is a global health concern, causing 5% of cancers, including cervical and oropharyngeal types.
- Current HPV vaccines, based on L1 VLPs, are effective against genital types but do not target skin HPV or offer therapeutic benefits.
Purpose of the Study:
- To summarize the progress and challenges of developing L2-based HPV vaccines.
- To address the limitations of existing L1 VLP vaccines regarding cutaneous HPV types and therapeutic potential.
Main Methods:
- Review of current research on L2-based HPV vaccine development.
- Analysis of strategies including capsid display, adjuvants, and fusions with early HPV antigens or TLR agonists.
Main Results:
- L2-based vaccines are under development to broaden coverage beyond genital HPV types.
- These novel vaccines aim to provide protection against cutaneous HPV and potentially offer therapeutic effects.
Conclusions:
- L2-based HPV vaccines represent a promising advancement to overcome limitations of current L1 VLP vaccines.
- Further research and development are crucial to realize the full potential of L2-targeting vaccines for public health.
Keywords:
L2adjuvantanogenital cancercapsid displaycervical cancerhuman papillomavirusmultimernon-melanoma skin canceroropharyngeal cancertoll-like receptor agonistMore Related Videos
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