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Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

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Emx1 Is Required for Neocortical Area Patterning.

Adam M Stocker¹, Dennis D M O'Leary¹

¹Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California, 92037, United States of America.

|February 23, 2016

Summary

The transcription factor Emx1 is crucial for neocortical area patterning. Its deletion alters frontal and motor areas, reducing the primary visual area and indicating Emx1

Area of Science:

Neuroscience
Developmental Biology
Genetics

Background:

Neocortical area patterning is essential for brain function.
Transcription factors with graded expression are implicated in this process.
Previous studies suggested Emx1 (Emx1) does not influence area patterning.

Purpose of the Study:

To investigate the role of Emx1 in neocortical area patterning.
To re-evaluate Emx1's function at later developmental stages.

Main Methods:

Analysis of two Emx1 deletion mouse models.
Examination of neocortical area features at mature stages.

Main Results:

Emx1 deletion led to expanded frontal and motor areas.

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The primary visual area was reduced following Emx1 deletion.

Neocortical areas exhibited a posterior-medial shift.

Conclusions:

Emx1 is a key transcription factor for neocortical area patterning.
Emx1 is required for the specification of the primary visual area.