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Related Experiment Videos

Respiratory muscle weakness and fatigue.

C M Laroche1, J Moxham, M Green

  • 1Respiratory Muscle Laboratory, Brompton Hospital, London.

The Quarterly Journal of Medicine
|May 1, 1989
PubMed
Summary

Quantifying respiratory muscle fatigue is complex, unlike measuring weakness. Research suggests a sequence of changes, not a single index, indicates fatigue, impacting respiratory muscle function.

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Area of Science:

  • Physiology
  • Neuromuscular Disorders

Background:

  • Respiratory muscle weakness stems from various neuromuscular disorders.
  • Reliable tests can quantify muscle weakness extent and patterns.
  • Quantifying respiratory muscle fatigue remains challenging.

Purpose of the Study:

  • To explore the complexities of quantifying respiratory muscle fatigue.
  • To understand the interplay of factors protecting respiratory muscles.
  • To identify new avenues for understanding ventilatory failure.

Main Methods:

  • Review of current understanding of respiratory muscle function.
  • Analysis of the challenges in fatigue quantification.
  • Exploration of adaptive changes in respiratory drive and pump capacity.

Main Results:

  • Respiratory muscle fatigue is characterized by a sequence of changes, not a single index.
  • Interplay between respiratory pump capacity, load, and drive protects against failure.
  • Overt peripheral contractile failure is prevented by adaptive mechanisms.

Conclusions:

  • Developing a single 'test of fatigue' is unlikely to be fruitful.
  • Investigating the inter-related processes of fatigue is more promising.
  • Improved understanding of respiratory muscle dysfunction in ventilatory failure is achievable.

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