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Updated: Mar 25, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
Published on: October 17, 2025
Complex genomic variants contribute toward the genetic architecture of autism spectrum disorder
Chia-Hsiang Chen1, Hsiao-Mei Liao, Hsin-I Chen
1aDepartment of Psychiatry, Chang Gung Memorial Hospital-Linkou Medical Center bDepartment and Graduate Institute of Biomedicine, Chang Gung University, Taoyuan cDepartment of Psychiatry, National Taiwan University Hospital and College of Medicine dDepartment of Life Sciences and Institute of Genome Sciences, National Yang-Ming University eGraduate Institute of Brain and Mind Sciences and Graduate Institute of Clinical Medicine, National Taiwan University, Taipei fCenter for Medical Genetics, Tzu-Chi General Hospital, Hualien, Taiwan gSection on Molecular Neurobiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Abstract:
Genetic factor plays a critical role in the etiology of autism spectrum disorder (ASD). Both common variants with a small effect and rare mutations with a large effect contribute toward the genetic basis of ASD, showing the high genetic heterogeneity of ASD. Genomic rearrangements account for around 10-15% of its genetic landscape. However, they are highly individualized and each of them has a very rare frequency.
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