Too Much, Too Little or Just Enough: A Goldilocks Effect for IL-13 and Skin Barrier Regulation?
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Jessica Strid1, W H Irwin McLean2, Alan D Irvine3
1Division of Immunology and Inflammation, Department of Medicine, Imperial College London, London, UK.
The Journal of Investigative Dermatology
|February 24, 2016
Abstract:
The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Hönzke and colleagues explore these interactions further. The effects of IL-4/ll-13 may be context dependent, with differing roles in homeostasis and in disease.

