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Evaluating Choroidal Characteristics in Systemic Sclerosis Using Enhanced Depth Imaging Optical Coherence Tomography.

Ebru Esen1, Didem Arslan Tas2, Selcuk Sizmaz1

  • 1a School of Medicine, Department of Ophthalmology , Cukurova University , Adana , Turkey.

Ocular Immunology and Inflammation
|February 24, 2016
PubMed
Summary

Systemic sclerosis (SSc) patients exhibit reduced choroidal thickness (CT), indicating potential vascular injury in ocular microcirculation. This finding highlights the impact of SSc on eye health.

Keywords:
Central macular thicknesschoroidal thicknessoptical coherence tomographysystemic sclerosisvasculopathy

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Vascular Biology

Background:

  • Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by widespread vascular damage.
  • Ocular microcirculation involvement in SSc is not fully understood.
  • Choroidal thickness (CT) is a potential indicator of ocular vascular health.

Purpose of the Study:

  • To evaluate choroidal thickness (CT) in patients with systemic sclerosis (SSc).
  • To investigate the involvement of choroidal circulation in SSc.
  • To assess potential correlations between SSc and ocular vascular changes.

Main Methods:

  • Enhanced depth imaging optical coherence tomography (EDI-OCT) was used for CT measurements.
  • CT was measured in the subfoveal, 1000 µm nasal, and 1000 µm temporal parafoveal regions.
  • 120 eyes of 60 SSc patients were compared with 60 eyes of 30 healthy controls.

Main Results:

  • SSc patients showed significantly reduced subfoveal CT compared to controls (297.77 ± 60.8 µm vs 339.8 ± 50.4 µm).
  • Parafoveal CT (nasal and temporal) was also significantly thinner in SSc patients.
  • All comparisons between SSc patients and controls were statistically significant (p<0.001).

Conclusions:

  • Reduced CT in SSc patients supports the hypothesis of widespread vascular injury.
  • This study suggests ocular microcirculation is affected in systemic sclerosis.
  • Choroidal thickness may serve as a biomarker for vascular complications in SSc.