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Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
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The mitochondrial permeability transition pore in AD 2016: An update

Lucia Biasutto1, Michele Azzolini1, Ildikò Szabò2

  • 1CNR Neuroscience Institute, Viale G. Colombo 3, 35121 Padova, Italy; University of Padova, Department of Biomedical Sciences, Viale G. Colombo 3, 35121 Padova, Italy.

Biochimica Et Biophysica Acta
|February 24, 2016
PubMed
Summary

The mitochondrial permeability transition pore, a key factor in cell death and disease, is being actively researched. Recent findings suggest the F-ATP synthase or SPG7 may form this pore, with ongoing debate about its exact molecular structure.

Keywords:
Cyclophilin DF(O)F(1) ATP synthaseMitochondrial permeability transition pore (mPTP)Spastic paraplegia 7 (SPG7)

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