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Published on: August 14, 2019
Lower urinary tract symptoms in children with anorectal malformations with rectoperineal fistulas
Pernilla Stenström1, Hanna Sandelin2, Ragnhild Emblem3
1Department of Pediatric Surgery, Skane University Hospital, Institution of Clinical Science, Lund University.
Insights
Children with anorectal malformations with rectoperineal fistulas (ARM-P) experience more lower urinary tract symptoms (LUTS) than healthy peers. Those with urinary tract anomalies (UTA) show increased LUTS, necessitating regular follow-up.
Area of Science:
- Pediatric Surgery
- Urology
- Congenital Malformations
Background:
- Anorectal malformations with rectoperineal fistulas (ARM-P) are congenital conditions that can impact multiple organ systems.
- Lower urinary tract symptoms (LUTS) are common in children but their prevalence in those with ARM-P requires further investigation.
Purpose of the Study:
- To determine the frequency of LUTS in children diagnosed with ARM-P.
- To compare LUTS prevalence in children with ARM-P against a control group, analyzing gender-specific differences.
- To assess the impact of concomitant urinary tract anomalies (UTA) on LUTS in the ARM-P cohort.
Main Methods:
- Utilized the International Children's Continence Society 2014 definitions for LUTS.
- Collected data from children aged 4-12 years undergoing surgery for ARM-P across two international pediatric surgery centers.
- Compared LUTS, urinary tract infections, and medication use between the ARM-P patient group and a control cohort, stratified by gender and presence of UTA.
Main Results:
- Children with ARM-P exhibited a higher incidence of LUTS compared to controls.
- The frequency of urinary tract infections and daily urinary medication use was significantly greater in the ARM-P group.
- Patients with co-occurring UTA reported more frequent urinary infections than those without UTA.
Conclusions:
- Children with ARM-P demonstrate a higher burden of LUTS than their healthy counterparts.
- The presence of concomitant UTA exacerbates LUTS in children with ARM-P.
- Routine screening for both UTA and LUTS is recommended for children diagnosed with ARM-P.
Aim:
The aim was to describe the frequency of lower urinary tract symptoms (LUTS) in children with anorectal malformations with rectoperineal fistulas (ARM-P), as compared with healthy controls based on gender.
Method:
LUTS were defined using the 2014 definitions of the International Children's Continence Society. Data were collected at 2 tertiary pediatric surgery centers in 2 countries from all children aged 4-12years who had undergone an operation for ARM-P.
Results:
A total of 24 girls and 33 boys, with a median age of 8 (4-12)years, were eligible and compared with 165 controls. Of the patient group, 4 (17%) girls had 8 urinary tract anomalies (UTA), and 8 (24%) boys had 13 UTA. There were no gender differences in LUTS among the patients. The frequency of urinary tract infections was higher among the patients (5/24 girls and 7/55 boys) than the controls (1/55 and 4/110) (p=0.009). More patients (5/24 girls and 5/33 boys) than controls (1/55 and 2/110) used daily urinary medications (p=0.009 and p=0.007, respectively). Patients with UTA reported urinary infections more frequently (3/4 girls and 4/8 boys) than those without UTA (2/20 girls and 0/25 boys) (p=0.018 and p=0.002, respectively).
Conclusion:
Children with ARM-P had more LUTS than controls, and patients with concomitant UTA had more LUTS than patients without UTA. Therefore, children with ARM-P are suggested to have routine follow-up for both UTA and LUTS.
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