[Total Pancreatectomy and Islet Autotransplantation in a Child with Recurrent Pancreatitis]

R Grützmann1, B Ludwig2, J Weitz3

  • 1Klinik für Allgemein- und Viszeralchirurgie, Universitätsklinikum Erlangen, Deutschland.

Zentralblatt Fur Chirurgie
|February 24, 2016
PubMed

Insights

Total pancreatectomy with islet autotransplantation offers pain relief for children with hereditary pancreatitis. This spleen-preserving surgery can prevent or reduce diabetes after pancreas removal.

Area of Science:

  • Pediatric Surgery
  • Endocrinology
  • Gastroenterology

Background:

  • Hereditary pancreatitis is a rare condition in children, often requiring surgical intervention for intractable pain and complications.
  • Current surgical options include duodenum-preserving resections and drainage, but recurrences are common due to diffuse pancreatic involvement.

Observation:

  • This video demonstrates a spleen-preserving total pancreatectomy with islet autotransplantation in a 10-year-old child with chronic recurrent pancreatitis.
  • The procedure involves reconstruction with hepatico-jejunostomy and duodeno-jejunostomy, followed by islet autotransplantation into the portal vein.

Findings:

  • Total pancreatectomy effectively manages pain in the majority of pediatric patients with symptomatic hereditary pancreatitis.
  • Combining total pancreatectomy with islet autotransplantation can attenuate or prevent pancreoprivic diabetes mellitus.

Implications:

  • Spleen-preserving total pancreatectomy is a safe and beneficial procedure for highly selected pediatric patients when performed by experienced surgeons.
  • This approach offers a significant advantage over purely symptomatic management for severe hereditary pancreatitis.
Abstract