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Related Concept Videos

Force01:06

Force

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Forces affect every moment of our life. Our bodies are held to the Earth by force, and they are held together by the forces of charged particles. When we open a door, walk down a street, lift a fork, or touch a baby's face, we are applying force. Our body's atoms are held together by electrical forces, and the core of an atom, called the nucleus, is held together by the strongest force known to us—nuclear force.
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Force and Momentum01:17

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Force and momentum are intimately related. Force acting over time can change momentum, and Newton's second law of motion can be stated in its most broadly applicable form in terms of momentum. Momentum can be applied to systems where the mass is changing, such as rockets, as well as to systems of constant mass. Also, momentum continues to be a key concept in the study of atomic and subatomic particles in quantum mechanics. One can consider systems with varying mass in some detail; however, the...
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Light as Energy01:35

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The energy required to carry out photosynthesis is light— typically electromagnetic radiation from the sun. The range of all possible wavelengths is known as the electromagnetic spectrum.
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Three Force Member01:27

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A rigid body subjected to three forces acting at three points is known as a three-force member. These forces must have concurrent lines of action, except for parallel forces, where the lines of action are parallel.
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Two Force Member01:30

Two Force Member

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The equilibrium of a two-force body is a particular case that is often encountered in practical applications. A two-force body is a rigid body that is subjected to only two external forces. For such a body to be in equilibrium, the two forces must have the same magnitude, the same line of action, and the opposite direction.
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Introduction to force01:25

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Consider water flowing from a nozzle to a turbine vane. As the water hits the turbine vane, it exerts a force that causes it to move along the flow of direction. Force is an impact that changes an object's motion, shape, or orientation. Forces can be caused by physical contact, such as a push or pull, or through non-contact interactions, such as magnetic or gravitational forces. Force is a vector quantity with both magnitude and direction, and is measured in newtons (N) in the SI unit...
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The light side of the force.

Aakash Basu1, Taekjip Ha2

  • 1Department of Biophysics and Biophysical Chemistry, Johns Hopkins University, Baltimore, United States.

Elife
|February 24, 2016
PubMed
Summary

Two single-molecule methods uncovered novel tertiary interactions within the TPP riboswitch. This finding advances our understanding of riboswitch structural dynamics and function.

Keywords:
TPPbiophysicsnoneoptical trapriboswitchsingle molecule biophysicssmFRETstructural biology

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • Riboswitches are regulatory RNA elements.
  • The TPP riboswitch controls gene expression in response to thiamine pyrophosphate.

Purpose of the Study:

  • To investigate the tertiary structure of the TPP riboswitch using advanced single-molecule techniques.
  • To identify previously uncharacterized interactions within the TPP riboswitch.

Main Methods:

  • Utilized a combination of two single-molecule biophysical techniques.
  • Applied advanced data analysis to resolve structural features.

Main Results:

  • Revealed novel tertiary interactions in the TPP riboswitch.
  • Provided high-resolution insights into the RNA structure.

Conclusions:

  • The identified tertiary interactions are crucial for TPP riboswitch function.
  • Single-molecule approaches offer powerful tools for RNA structure elucidation.