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Related Concept Videos

Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
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The connective tissues have different properties and functions in the human body. They are broadly categorized into proper, supporting, or fluid connective tissues.
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Ocular involvement in cutaneous connective tissue disease.

Frank A Santoro1, John Huang2

  • 1Department of Dermatology, University of Connecticut Health Center, 21 South Road, 2nd Floor, Farmington, CT 06032.

Clinics in Dermatology
|February 24, 2016
PubMed
Summary

Connective tissue disorders can affect the skin and eyes, potentially causing vision loss. Early recognition of eye symptoms in patients with these conditions is crucial for timely ophthalmologic evaluation and preventing blindness.

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Area of Science:

  • Ophthalmology
  • Dermatology
  • Rheumatology

Background:

  • Connective tissue disorders frequently impact multiple organ systems, notably the skin and eyes.
  • The microvasculature of these organs is often affected by the pathogenesis of these systemic diseases.
  • Ocular manifestations can be early indicators of underlying connective tissue disease.

Purpose of the Study:

  • To highlight the significance of ocular involvement in connective tissue disorders.
  • To emphasize the link between cutaneous and ocular manifestations.
  • To underscore the importance of ophthalmologic evaluation in patients with connective tissue diseases.

Main Methods:

  • Review of existing literature on connective tissue disorders and their ocular manifestations.
  • Analysis of clinical presentations linking dermatologic and ophthalmologic findings.
  • Emphasis on the role of dermatologists in identifying potential eye disease.

Main Results:

  • Ocular symptoms such as redness, dryness, pain, and vision loss may signal eye disease in connective tissue disorder patients.
  • Ocular involvement can lead to severe vision impairment, including blindness.
  • Recognition of these symptoms necessitates prompt referral to an ophthalmologist.

Conclusions:

  • Ocular involvement is a critical, often overlooked, aspect of connective tissue disorders.
  • Dermatologists play a key role in the early detection of ocular complications.
  • Timely ophthalmologic assessment is essential to prevent vision loss and manage systemic disease.