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Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
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Hake fish bone as a calcium source for efficient bone mineralization.

Lisa Flammini1, Francesca Martuzzi2, Valentina Vivo1

  • 1a Department of Pharmacy , University of Parma , Parma , Italy ;

International Journal of Food Sciences and Nutrition
|February 24, 2016
PubMed
Summary
This summary is machine-generated.

Hake fish bone (HBF) effectively supplements calcium for bone health, showing comparable results to Lithotame (L) in both in vitro and in vivo studies. This fish industry by-product is a viable calcium source for bone mineralization.

Keywords:
Calciumdiet supplementhake bone flourlithotamephosphate

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Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts
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Area of Science:

  • Nutritional Science
  • Biochemistry
  • Biomaterials

Background:

  • Calcium is vital for achieving and maintaining optimal bone mass, especially during growth and in old age.
  • Dietary calcium intake is crucial for bone health throughout the lifespan.
  • Investigating novel, sustainable calcium sources is important for nutritional supplementation.

Purpose of the Study:

  • To assess the efficacy of hake fish bone (HBF) as a calcium source for bone mineralization.
  • To compare HBF's effectiveness against a commercial calcium supplement, Lithotame (L).
  • To evaluate HBF's performance in both in vitro and in vivo models.

Main Methods:

  • In vitro: Osteosarcoma SaOS-2 cells cultured in calcium-free osteogenic medium (OM) supplemented with HBF or L.
  • In vivo: Young growing rats fed a low-calcium diet supplemented with HBF or L.
  • Analysis of physico-chemical parameters: femur breaking force, tibia density, and calcium/phosphorus content.

Main Results:

  • In vitro, HBF supplementation supported bone mineralization comparable to standard OM; L showed lower activity.
  • In vivo, both HBF and L diets similarly promoted bone deposition in rats on a low-calcium diet.
  • Both calcium supplements demonstrated beneficial effects on bone mineralization parameters without adverse effects.

Conclusions:

  • Hake fish bone (HBF) is an effective calcium supplier derived from a fish industry by-product.
  • HBF exhibits comparable efficacy to Lithotame (L) as a calcium source for bone health.
  • HBF presents a promising alternative for calcium supplementation, supporting bone mineralization.