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Regulation of FGF signaling: Recent insights from studying positive and negative modulators

Lina Korsensky1, Dina Ron1

  • 1Department of Biology, Technion, Israel Institute of Technology, Haifa 3200003, Israel.

Seminars in Cell & Developmental Biology
|February 24, 2016
PubMed

Insights

Fibroblast growth factor (FGF) signaling regulates biological processes but its impairment causes diseases. This review highlights anosmin-1, FLRT3, and Sef proteins that modulate FGF signaling, impacting human health.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Developmental Biology

Background:

  • Fibroblast growth factor (FGF) signaling is crucial for numerous biological functions.
  • Dysregulation of FGF signaling is linked to human diseases, including developmental disorders and cancer.

Purpose of the Study:

  • To review the positive and negative modulators of FGF signaling.
  • To examine the regulatory roles of anosmin-1, fibronectin-leucine-rich transmembrane protein 3 (FLRT3), and similar expression to FGF (Sef).
  • To explore the implications of these regulators in human diseases.

Main Methods:

  • Literature review of recent findings on FGF signaling modulators.
  • Analysis of protein interactions and regulatory mechanisms.
  • Cross-species comparison of FGF pathway regulation.

Main Results:

  • Anosmin-1, FLRT3, and Sef are key protein regulators of FGF signaling.
  • These proteins modulate FGF activity at multiple distinct levels.
  • The identified regulators play significant roles across different species.

Conclusions:

  • Understanding FGF signaling modulation is vital for comprehending its role in health and disease.
  • Anosmin-1, FLRT3, and Sef represent important targets for therapeutic intervention.
  • Further research into these regulators can illuminate disease mechanisms and potential treatments.

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