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International Developments in the Care of Familial Hypercholesterolemia: Where Now and Where to Next?

Jing Pang1, Peter J Lansberg, Gerald F Watts

  • 1School of Medicine and Pharmacology, University of Western Australia.

Journal of Atherosclerosis and Thrombosis
|February 24, 2016
PubMed

Insights

Familial hypercholesterolemia (FH) care guidelines exist, but systematic screening programs are lacking globally. This study reviews international initiatives to improve FH detection and treatment worldwide.

Area of Science:

  • Cardiology
  • Genetics
  • Public Health

Background:

  • International guidelines for familial hypercholesterolemia (FH) care are available.
  • These guidelines cover case detection, cascade testing, pediatric protocols, treatment strategies, and apheresis indications.
  • Most countries lack systematic FH screening programs for community-based detection and treatment.

Purpose of the Study:

  • To provide a comprehensive overview of current and future international initiatives for familial hypercholesterolemia (FH) care.
  • To address the gaps in FH detection and treatment at a global level.

Main Methods:

  • Review of recent international guidelines and consensus statements on FH care.
  • Analysis of current and proposed international initiatives for FH screening and management.

Main Results:

  • Agreement exists on various aspects of FH care, including detection, testing, treatment, and apheresis.
  • Significant disparities persist in the implementation of systematic FH screening programs worldwide.

Conclusions:

  • Despite established guidelines, global implementation of FH care remains insufficient.
  • International initiatives are crucial for bridging the gaps in FH detection and treatment, improving patient outcomes.

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