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Heart disease in systemic sclerosis.

D L Janosik¹, T G Osborn, T L Moore

¹Division of Rheumatology, St. Louis University School of Medicine, MO 63104.

Seminars in Arthritis and Rheumatism

|December 1, 1989

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Systemic sclerosis (SSc) often involves the heart, leading to conditions like pericardial and myocardial disease. Early detection and improved diagnostics are crucial for managing cardiac complications in SSc patients.

Area of Science:

Cardiology
Rheumatology
Immunology

Background:

Systemic sclerosis (SSc) frequently presents with cardiovascular manifestations.
Cardiac abnormalities are found in over half of SSc patients at autopsy.
Subclinical cardiac involvement in SSc is increasingly recognized.

Purpose of the Study:

To highlight the prevalence and types of cardiac involvement in SSc.
To discuss advancements in noninvasive diagnostic modalities for early detection.
To review current treatment strategies and future research directions for cardiac SSc.

Main Methods:

Review of existing literature on cardiac manifestations in SSc.
Discussion of noninvasive diagnostic tools such as echocardiography, radionucleotide imaging, and ambulatory ECG.

Related Experiment Videos

Analysis of current therapeutic approaches and the need for clinical trials.

Main Results:

Primary cardiac issues in SSc include pericardial disease, myocardial disease, conduction abnormalities, and arrhythmias.
Noninvasive imaging and monitoring techniques enable early detection of asymptomatic cardiac involvement.
Current treatments are largely symptomatic and empirical.

Conclusions:

Improved diagnostic capabilities allow for earlier identification of cardiac involvement in SSc.
There is a critical need for prospective randomized trials to evaluate preventive therapies.
Advances in understanding SSc pathogenesis and new therapeutic agents hold promise for improving outcomes.