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Rotating for elongation: Fat2 whips for the race
Tomke Stürner1, Gaia Tavosanis2
1Dendrite Differentiation, German Center for Neurodegenerative Diseases, 53115 Bonn, Germany.
Abstract:
Dynamic rearrangements of the actin cytoskeleton are crucial for cell shape and migration. In this issue, Squarr et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201508081) show that the cadherin superfamily protein Fat2 regulates actin-rich protrusions driving collective cell migration during Drosophila melanogaster egg morphogenesis through its interaction with the WAVE regulatory complex.
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