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Related Concept Videos

Long-term Potentiation01:25

Long-term Potentiation

3.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
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Long-term Potentiation01:35

Long-term Potentiation

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: Mar 25, 2026

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
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Long-term Potentiation at Temporoammonic Path-CA1 Synapses in Freely Moving Rats.

Jossina Gonzalez1, Desiree M Villarreal1, Isaiah S Morales1

  • 1Department of Biology, University of Texas at San Antonio San Antonio, TX, USA.

Frontiers in Neural Circuits
|February 24, 2016
PubMed
Summary

Long-term potentiation (LTP) at medial temporoammonic path (mTAP)-CA1 synapses in rats was characterized in vivo. This study reveals robust and long-lasting synaptic plasticity in the hippocampus, crucial for memory function.

Keywords:
CA1LTPcurrent source densityin vivotemporoammonic path

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Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Hippocampal Function

Background:

  • The temporoammonic path (TAP) provides direct input to hippocampal area CA1.
  • TAP-CA1 synapses are implicated in memory, but their in vivo plasticity is poorly understood.

Purpose of the Study:

  • To characterize the induction and longevity of long-term potentiation (LTP) at medial TAP (mTAP)-CA1 synapses in vivo.
  • To investigate the physiological relevance of TAP input to CA1.

Main Methods:

  • Analysis of CA1 responses to medial angular bundle stimulation in freely moving rats.
  • Induction of LTP using theta burst high frequency stimulation of mTAP afferents.
  • Measurement of LTP decay over time.

Main Results:

  • Monosynaptic mTAP-CA1 responses were isolated in vivo.
  • Putative population spikes were observed in 40% of animals.
  • N-methyl-D-aspartate (NMDA) receptor-dependent LTP was induced, showing long-lasting decay with time constants of 2.7 and 148 days.

Conclusions:

  • The medial temporoammonic path is a physiologically relevant system for CA1.
  • mTAP-CA1 synapses exhibit robust and enduring synaptic plasticity in vivo.
  • These findings contribute to understanding hippocampal memory mechanisms.