Zosteriform spiradenoma with spiradenocarcinoma: A rare entity

Area of Science:

• Dermatology
• Oncology

Background:

• Eccrine spiradenoma (ES) is a rare, benign sweat gland tumor typically presenting as a solitary lesion in adults.
• Multiple ES, particularly in a linear or zosteriform distribution, are exceptionally uncommon.

Observation:

• A case study of a 23-year-old female with multiple eccrine spiradenomas.
• The lesions were arranged in a zosteriform (shingles-like) pattern.
• One of the multiple eccrine spiradenomas showed malignant transformation over a 10-year period.

Findings:

• This case highlights the rare occurrence of multiple eccrine spiradenomas in a zosteriform pattern.
• It also demonstrates the potential for malignant transformation of eccrine spiradenoma into spiradenocarcinoma over time.

Implications:

• This case underscores the importance of long-term monitoring for patients with multiple eccrine spiradenomas.
• It suggests that even benign eccrine spiradenomas may carry a risk of malignant transformation, necessitating vigilance.