Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

5.7K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
5.7K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

4.2K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.2K
The Thyroid Gland01:23

The Thyroid Gland

8.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
8.6K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

7.8K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
7.8K
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

5.3K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
5.3K
Bone Remodeling01:40

Bone Remodeling

41.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical profile of scrub typhus at a tertiary care hospital in northern India.

Indian journal of medical microbiology·2026
Same author

Auricular Chondritis and Renal Medullary Angiitis - An Uncommon Manifestation of Antineutrophilic Cytoplasmic Antibody Associated Vasculitis.

Indian journal of nephrology·2025
Same author

Unusual Late Onset Recurrent Venous Thrombosis in Two Young Post Renal Transplant Recipients - Challenges in Diagnosis and Management with Review of Literature.

Indian journal of nephrology·2025
Same author

Prevalence and clinical correlates of splenomegaly in sickle cell disease patients: An observational study in Western India.

Medical journal, Armed Forces India·2025
Same author

Vitamin D deficiency presenting as seizures.

Medical journal, Armed Forces India·2025
Same author

Serum Procalcitonin vs SOFA Score in Predicting Outcome in Sepsis Patients in Medical Intensive Care Unit.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2023

Related Experiment Video

Updated: Mar 25, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

5.2K

Primary hyperparathyroidism: A changing scenario in India.

Sangeeta Jha1, Muthukrishnan Jayaraman2, Aman Jha3

  • 1Department of Endocrinology and Endocrine Surgery, Care Hospital, Hyderabad, Telangana, India.

Indian Journal of Endocrinology and Metabolism
|February 24, 2016
PubMed
Summary
This summary is machine-generated.

Primary hyperparathyroidism (PHPT) is diagnosed earlier now, with fewer pathological fractures. Increased awareness and Vitamin D (Vit D) supplementation have reduced disease severity, leading to effective cures.

Keywords:
Parathyroid adenomaVitamin D deficiencyprimary hyperparathyroidism

More Related Videos

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.4K
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

15.4K

Related Experiment Videos

Last Updated: Mar 25, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

5.2K
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.4K
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

15.4K

Area of Science:

  • Endocrinology
  • Metabolic Bone Disease

Background:

  • Primary hyperparathyroidism (PHPT) presents with diverse systemic issues, often alongside Vitamin D (Vit D) deficiency.
  • Evolving awareness, diagnostic advancements, and Vit D supplementation may alter PHPT's clinical presentation.

Purpose of the Study:

  • To compare the clinical, biochemical, and pathological profiles of PHPT patients over two distinct time periods.
  • To assess the impact of increased awareness and improved diagnostics on PHPT presentation and outcomes.

Main Methods:

  • A retrospective analysis of 110 PHPT cases presenting to a South Indian tertiary care center.
  • Patients were divided into two groups based on presentation period: Group A (1994-2007) and Group B (2007-2015).
  • Clinical data, biochemical markers, and pathological findings were compared between the two groups.

Main Results:

  • PHPT continues to affect females predominantly, with a similar age at presentation.
  • Diagnosis occurs earlier in Group B (26 months) compared to Group A (38.7 months).
  • Bone pain and myopathy are common (60%), pathological fractures are less frequent (16%), and Vitamin D deficiency remains prevalent.

Conclusions:

  • PHPT is increasingly diagnosed earlier, presenting with reduced morbidity despite persistent bone and stone-related symptoms.
  • Enhanced awareness, Vitamin D supplementation, and advanced diagnostics contribute to better management and cure rates for PHPT.