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Trimester specific reference intervals for thyroid function tests in normal Indian pregnant women.

Tarun Sekhri1, Juhi Agarwal Juhi2, Reena Wilfred1

  • 1Division of Endocrinology and Thyroid Research, Institute of Nuclear Medicine and Allied Sciences, Timarpur, New Delhi, India.

Indian Journal of Endocrinology and Metabolism
|February 24, 2016
PubMed
Summary

This study establishes trimester-specific reference intervals for thyroid function tests in pregnant Indian women. These new thyroid hormone levels are crucial for accurate diagnosis and management during pregnancy.

Keywords:
Anti-thyroid peroxidasepregnant womenreference intervalsthyroid function teststrimester

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Area of Science:

  • Endocrinology
  • Obstetrics
  • Clinical Chemistry

Background:

  • Accurate thyroid function assessment is vital during pregnancy for managing thyroid hormone therapy and dosages in hypothyroid cases.
  • Thyroid dysfunction in pregnancy can impact both maternal and fetal health outcomes.

Purpose of the Study:

  • To establish trimester-specific reference intervals for thyroid function tests in pregnant Indian women.
  • To evaluate thyroid function in pregnant women without a history of thyroid disorders across all trimesters.

Main Methods:

  • Studied 86 healthy, euthyroid pregnant women and 124 non-pregnant controls.
  • Measured thyrotropin (TSH), free thyroxine (FT4), free triiodothyronine (FT3), and anti-TPO using Roche Elecsys 1010.
  • Calculated 2.5th and 97.5th percentiles for reference intervals, with urinary iodine levels also assessed.

Main Results:

  • Established trimester-specific reference intervals for TSH, FT4, and FT3.
  • Observed significant differences in thyroid hormone concentrations across pregnancy trimesters.
  • Median urinary iodine concentration was 150-200 µg/l throughout pregnancy.

Conclusions:

  • Trimester-specific reference intervals for thyroid tests in pregnant Indian women were successfully established.
  • These intervals, determined using the 2.5th and 97.5th percentiles, aid in precise thyroid function assessment during gestation.
  • The findings support improved clinical management of thyroid disorders in pregnant populations.