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Polydextrose Enhances Calcium Absorption and Bone Retention in Ovariectomized Rats
Adriana R Weisstaub1, Victoria Abdala1, Macarena Gonzales Chaves2
1Food Science and Nutritional Department, School of Pharmacy and Biochemistry, Buenos Aires University (UBA), 1114 Buenos Aires, Argentina.
International Journal of Food Science
|February 24, 2016
Summary
Polydextrose (PDX) enhanced calcium absorption and helped prevent bone loss in ovariectomized rats. This dietary fiber shows promise for bone health in models of osteoporosis.
Area of Science:
- Nutrition Science
- Bone Metabolism Research
- Gastrointestinal Physiology
Background:
- Ovariectomy in rats is a common model for postmenopausal osteoporosis.
- Calcium bioavailability and bone mineral density are critical factors in bone health.
- Dietary fibers can influence mineral absorption and bone metabolism.
Purpose of the Study:
- To investigate the impact of polydextrose (PDX) on calcium (Ca) bioavailability.
- To assess PDX's efficacy in preventing bone mass loss in an ovariectomized rat model.
- To compare PDX with fructooligosaccharides (FOS) as a fiber source.
Main Methods:
- Ovariectomized (OVX) and SHAM-operated rats were fed diets with PDX, FOS, or a control diet for 60 days.
- Measurements included apparent calcium absorption (%ABS), bone mineral content (BMC), bone mineral density (BMD), and femur composition.
- Caecal parameters such as weight and pH were also analyzed.
Main Results:
- Both PDX and FOS increased apparent calcium absorption and caecal weight while lowering caecal pH compared to OVX controls.
- PDX and FOS groups showed significantly higher bone mineral density and total skeleton bone mineral content than the OVX group.
- % Bone Volume and femur calcium content were significantly higher in the PDX group compared to the FOS group.
Conclusions:
- Polydextrose (PDX) supplementation effectively enhances calcium absorption in rats.
- PDX demonstrates a protective effect against bone loss in an ovariectomized model.
- PDX shows potential as a dietary intervention for improving bone health.
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