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Poly(ADP-Ribose) Polymerase in Cervical Cancer Pathogenesis: Mechanism and Potential Role for PARP Inhibitors

Ioannis C Kotsopoulos1, Ali Kucukmetin, Asima Mukhopadhyay

  • 1*Northern Gynaecological Oncology Centre, Queen Elizabeth Hospital, Gateshead; and †Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom.

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
|February 25, 2016
PubMed

Insights

Poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors show promise for treating advanced cervical cancer, offering a targeted approach beyond palliative chemotherapy. Research is ongoing to evaluate their efficacy and role in cervical carcinomas.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Limited treatment options exist for recurrent advanced cervical cancer, primarily palliative chemotherapy with low efficacy.
  • There is a critical need for novel targeted therapeutic agents.
  • Poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors (PARPi) are a promising class of agents for DNA repair-deficient cancers.

Purpose of the Study:

  • To review the role of PARP in cervical intraepithelial neoplasia and invasive cervical cancer.
  • To explore PARP expression, mechanism of action, and the impact of polymorphisms in cervical cancer pathogenesis.
  • To evaluate the therapeutic potential of PARP inhibitors in cervical cancer.

Main Methods:

  • Comprehensive literature review of existing studies on PARP and PARPi in cervical cancer.
  • Analysis of PARP expression, function, and genetic polymorphisms.
  • Evaluation of data from ongoing clinical trials of PARPi in cervical cancer.

Main Results:

  • PARP plays a significant role in cervical cancer development and progression.
  • PARPi demonstrate therapeutic potential, with several clinical trials underway.
  • Understanding PARP's role may lead to new treatment strategies.

Conclusions:

  • PARP inhibitors represent a promising targeted therapy for advanced and recurrent cervical cancer.
  • Further research and clinical trials are essential to establish the efficacy of PARPi.
  • A new unifying theory on the role of PARPs in cervical carcinoma development is proposed.

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