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Methionine synthase A2756G transition might be a risk factor for male infertility: Evidences from seven case-control

Mohammad Karimian1, Abasalt Hosseinzadeh Colagar2

  • 1Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran.

Molecular and Cellular Endocrinology
|February 25, 2016
PubMed

Insights

The methionine synthase (MTR) A2756G gene variant is linked to male infertility. This genetic factor may serve as a biomarker for diagnosing idiopathic male infertility.

Area of Science:

  • Genetics
  • Molecular Biology
  • Reproductive Medicine

Background:

  • Methionine synthase (MTR) is vital for DNA synthesis and methylation.
  • Genetic variations in MTR may influence male reproductive health.
  • Idiopathic male infertility affects a significant portion of the population.

Purpose of the Study:

  • To investigate the association between the MTR-A2756G polymorphism and idiopathic male infertility.
  • To evaluate the impact of the A2756G substitution on MTR protein structure and function.

Main Methods:

  • Genotyping of the MTR-A2756G polymorphism using PCR-RFLP in infertile men and healthy controls.
  • Conducting a meta-analysis combining current data with previous studies.
  • Utilizing bioinformatics tools to assess the structural effects of the A2756G substitution on MTR protein.

Main Results:

  • The AG-genotype, GG-genotype, and G-allele of MTR were significantly associated with male infertility in the study cohort.
  • Meta-analysis confirmed a significant association between the MTR A2756G transition and male infertility.
  • Bioinformatics analysis indicated that the A2756G substitution significantly impacts MTR protein function.

Conclusions:

  • The MTR A2756G polymorphism is a potential genetic risk factor for idiopathic male infertility.
  • This genetic variation may serve as a predictive biomarker for male infertility.
  • Further research is warranted to elucidate the precise mechanisms linking MTR A2756G to infertility.
Keywords:
BioinformaticsMTR geneMale infertilityMeta-analysisPolymorphism

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