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Related Concept Videos

Vaccine Production01:23

Vaccine Production

33
Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
33

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Development of Leishmania Species Strains with Constitutive Expression of eGFP
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Delivery systems for Leishmania vaccine development.

Elham Gholami1,2, Farnaz Zahedifard1, Sima Rafati1

  • 1a Department of Immunotherapy and Leishmania Vaccine Research , Pasteur Institute of Iran , Tehran , Iran (the Islamic Republic of).

Expert Review of Vaccines
|February 25, 2016
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Summary

Developing effective vaccines for leishmaniasis, a neglected tropical disease, is crucial. This review summarizes recent advancements in using delivery vehicles to enhance antigen efficacy for potential leishmaniasis vaccines.

Keywords:
Leishmaniasischemical delivery systemlive delivery systemnano/microparticleprotective immune responsesvaccination

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Area of Science:

  • * Parasitology and Tropical Medicine
  • * Vaccine Development and Immunology

Background:

  • * Leishmaniasis is a neglected tropical disease prevalent worldwide.
  • * Natural immunity post-recovery suggests vaccination potential.
  • * Current vaccine candidates lack sufficient safety and efficacy for human use.

Purpose of the Study:

  • * To review recent strategies for developing leishmaniasis vaccines.
  • * To explore the use of delivery vehicles for enhancing vaccine efficacy.
  • * To summarize advancements in antigen delivery systems for leishmaniasis.

Main Methods:

  • * Comprehensive literature review of recent research on leishmaniasis vaccine development.
  • * Analysis of studies employing various antigen delivery vehicles.
  • * Synthesis of findings on the immunogenicity and efficacy of tested vaccine approaches.

Main Results:

  • * Various antigens have shown promise but require effective delivery systems.
  • * Live and chemical carriers are being investigated to boost immune responses.
  • * Recent attempts focus on optimizing antigen presentation and stability.

Conclusions:

  • * Effective vaccine development for leishmaniasis necessitates improved antigen delivery.
  • * Delivery vehicles are critical for enhancing the safety and efficacy of leishmaniasis vaccines.
  • * Further research into robust delivery systems is essential for a viable leishmaniasis vaccine.