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Updated: Mar 25, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
Staphylococcus aureus and Streptococcus pneumoniae interaction and response to pneumococcal vaccination: Myth or
Aylana Reiss-Mandel1,2, Gili Regev-Yochay1,2
1a Epidemiology of Infectious Diseases Section; Gertner Institute ; Tel-Hashomer , Israel.
Abstract:
S. aureus and S. pneumoniae are both common pathogens that are also carried by a large proportion of healthy individuals in the nasal and nasopharyngeal spaces. A negative association between carriage of S. aureus and S. pneumoniae has been reported in children in various epidemiologic studies from different geographical regions. Most studies found that the negative association between S. pneumoniae and S. aureus was significant only for carriage of vaccine-type S. pneumoniae strains. In this review, we summarize the various suggested mechanisms of this suggested bacterial interference, and the clinical implications reported following PCV introduction to date in various geographical regions.
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