Amygdala, depression and drug treatment

The problem of the mechanisms of depression and action of the depressive drugs needs theoretical analysis and multichannel investigations. Animal models of depression are important for such investigations. Various neurochemical behavioral and psychological models were analysed in the present paper. Amygdalar model of depression seems to be one of the most important models. The effects of the treatment by amphetamine, imipramine and chlorpromazine on the amygdalar depressive syndrome in dogs were described. The individual differences were stressed, both in respect to forms of particular depression and to the sensitivity to drug treatment.