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Updated: Mar 25, 2026

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Hypertension in Primary Open Angle Glaucoma.

S Pokharel1, D Sherpa2, O K Malla1

  • 1Department of Ophthalmology, Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal.

JNMA; Journal of the Nepal Medical Association
|February 25, 2016
PubMed
Summary
This summary is machine-generated.

Age over 50, male gender, and low diastolic perfusion pressure are key risk factors for primary open-angle glaucoma (POAG). Understanding these factors is crucial for POAG development and management.

Keywords:
diastolic blood pressure; diastolic perfusion pressure; POAG; systolic blood pressure; systolic perfusion pressure.

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Area of Science:

  • Ophthalmology
  • Cardiovascular Health
  • Public Health

Background:

  • Vascular factors' impact on primary open-angle glaucoma (POAG) is debated, with conflicting reports on blood pressure. However, reduced ocular perfusion pressure is frequently observed.
  • Hypertension's specific role in POAG pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the association between hypertension and primary open-angle glaucoma (POAG).
  • To identify specific vascular and demographic factors contributing to POAG risk.

Main Methods:

  • A hospital-based, cross-sectional case-control study was conducted from June 2012 to June 2013.
  • The study included 40 POAG cases and 100 hypertensive controls without glaucoma.
  • Hypertension's role was compared between POAG patients and controls.

Main Results:

  • Age over 50 (OR: 4.83), male gender (OR: 3.10), and low diastolic perfusion pressure (OR: 3.86) showed strong positive associations with POAG.
  • High systolic (OR: 1.48) and diastolic blood pressure (OR: 1.35), and low systolic perfusion pressure (OR: 1.87) had weaker associations with POAG.

Conclusions:

  • Advanced age (over 50), male sex, and diminished diastolic perfusion pressure are significant risk factors for developing POAG.
  • These findings highlight critical demographic and hemodynamic factors in POAG etiology.