Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioreactor Controls-II01:18

Bioreactor Controls-II

13
In aerobic fermentations, oxygen is vital for microbial growth and metabolite production. Since air comprises only about 20% oxygen and the gas is poorly soluble in water—just 9 ppm at 20°C—supplying sufficient oxygen becomes a critical challenge, especially in high-demand processes like yeast growth or citric acid production. Even a fully saturated broth may offer only a few seconds of oxygen availability.To address this, sterile or scrubbed air is introduced into the...
13
Bioreactor Design and Operational System01:29

Bioreactor Design and Operational System

27
Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...
27
Scale-Up Processes01:14

Scale-Up Processes

30
The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
30
Bioreactor Controls-I01:28

Bioreactor Controls-I

24
Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly...
24
Designing Growth Media for Bioreactors01:30

Designing Growth Media for Bioreactors

18
Growth media provide essential nutrients that support cell growth and metabolism, thereby enhancing the yield of valuable products such as enzymes, antibiotics, and biomass. Designing an effective growth medium involves balancing all components to prevent nutrient limitations or toxic excesses, both of which can impair growth and reduce product yields.Composition of a Typical Growth MediumA typical growth medium contains carbon and nitrogen sources, salts, vitamins, trace elements, and...
18
Biofuels01:25

Biofuels

41
The microbial conversion of organic matter into biofuels holds potential as a renewable energy source. Among biofuel sources, microalgae are recognized as a highly efficient and adaptable feedstock for biodiesel production, owing to their rapid biomass accumulation, elevated lipid productivity, and capacity to proliferate in diverse aquatic systems, including freshwater, marine, and wastewater habitats. Unlike terrestrial crops, microalgae do not compete for land and can achieve significantly...
41

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elevation of Beta-2 Microglobulin during Prion Infection is Closely Correlated with PrP<sup>Sc</sup> Accumulation and is Independent of MHC-I.

ACS chemical neuroscience·2026
Same author

Spatially resolved nitrous oxide emissions in wastewater treatment processes.

Water research·2026
Same author

The clinical efficacy of hydrogen combined with tetrandrine in the treatment of silicosis fibrosis: A randomized controlled intervention study.

Respiratory medicine·2026
Same author

Effects of Antibiotic-Induced Gut Microbiota Dysbiosis on Arsenic Bioaccumulation and Transformation in Mice and Its Potential Mechanisms.

Environment & health (Washington, D.C.)·2026
Same author

Molecular Engineering of Emitters Toward Synergistic Hot-Exciton Harvesting and Light Outcoupling for High-Efficiency OLEDs.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt-Jakob Disease With T188K Mutation.

Annals of clinical and translational neurology·2026

Related Experiment Video

Updated: Mar 25, 2026

A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities
08:13

A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities

Published on: December 25, 2015

18.0K

Reducing aeration energy consumption in a large-scale membrane bioreactor: Process simulation and engineering

Jianyu Sun1, Peng Liang1, Xiaoxu Yan1

  • 1State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing, 100084, China.

Water Research
|February 25, 2016
PubMed
Summary

This study introduces an ammonia-nitrogen feedback control for membrane bioreactors (MBRs), significantly cutting aeration energy. This strategy reduced aeration by 20% in a large-scale test, lowering energy use in wastewater treatment.

Keywords:
Ammonia-N-based aeration control strategyEngineering applicationMembrane bioreactorSimulation

More Related Videos

Coupling Carbon Capture from a Power Plant with Semi-automated Open Raceway Ponds for Microalgae Cultivation
08:17

Coupling Carbon Capture from a Power Plant with Semi-automated Open Raceway Ponds for Microalgae Cultivation

Published on: August 14, 2020

6.1K
Optimize Flue Gas Settings to Promote Microalgae Growth in Photobioreactors via Computer Simulations
14:33

Optimize Flue Gas Settings to Promote Microalgae Growth in Photobioreactors via Computer Simulations

Published on: October 1, 2013

15.0K

Related Experiment Videos

Last Updated: Mar 25, 2026

A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities
08:13

A Novel Bioreactor for High Density Cultivation of Diverse Microbial Communities

Published on: December 25, 2015

18.0K
Coupling Carbon Capture from a Power Plant with Semi-automated Open Raceway Ponds for Microalgae Cultivation
08:17

Coupling Carbon Capture from a Power Plant with Semi-automated Open Raceway Ponds for Microalgae Cultivation

Published on: August 14, 2020

6.1K
Optimize Flue Gas Settings to Promote Microalgae Growth in Photobioreactors via Computer Simulations
14:33

Optimize Flue Gas Settings to Promote Microalgae Growth in Photobioreactors via Computer Simulations

Published on: October 1, 2013

15.0K

Area of Science:

  • Environmental Engineering
  • Water Treatment Technologies
  • Process Control

Background:

  • Membrane Bioreactors (MBRs) are crucial for wastewater treatment.
  • Reducing energy consumption, especially aeration, is vital for MBRs' wider adoption.
  • Current aeration control methods lack real-time optimization.

Purpose of the Study:

  • To develop and evaluate an in situ ammonia-nitrogen-based feedback control strategy for MBR aeration.
  • To reduce energy consumption in aerobic tanks within MBR systems.
  • To validate the strategy through model simulation and large-scale engineering application.

Main Methods:

  • Developed a full-scale MBR model based on the Activated Sludge Model (ASM).
  • Implemented a two-step cascaded proportion-integration (PI) feedback algorithm for aeration control.
  • Optimized algorithm parameters via simulation and tested on a 50,000 m(3)/d MBR.

Main Results:

  • Aeration flow rate was reduced by 15-20% in simulations.
  • A 20% reduction in aeration flow rate was achieved in the large-scale application.
  • Overall specific energy consumption decreased by 4% to 0.45 kWh/m(3)-effluent.

Conclusions:

  • The ammonia-nitrogen-based aeration control strategy effectively reduces energy consumption in MBRs.
  • The strategy demonstrates significant potential for real-time aeration optimization in full-scale wastewater treatment.
  • Further energy savings are anticipated with variable-frequency blowers.