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Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
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The uncinate fasciculus as observed using diffusion spectrum imaging in the human brain.
Bing Leng1, Siyuan Han2, Yijun Bao1
1Department of Neurosurgery, the First Affiliated Hospital of China Medical University, No.155, North Nanjing Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.
Neuroradiology
|February 25, 2016
Summary
The uncinate fasciculus (UF) connects the temporal lobe to the frontal cortex. This study found the UF has leftward asymmetry, differing from previous segmentation findings.
Area of Science:
- Neuroanatomy
- Neuroimaging
- White Matter Tractography
Background:
- The precise structure and function of the uncinate fasciculus (UF) remain unclear.
- Mapping the UF is crucial for understanding brain connectivity.
Purpose of the Study:
- To map the human UF white matter tractography.
- To investigate UF asymmetry, connectivity, and segmentation.
Main Methods:
- Diffusion spectrum imaging (DSI) and microdissection were used.
- Analysis included 9 healthy subjects and a 30-subject DSI template (CMU-30).
Main Results:
- The UF connects the anterior temporal lobe (superior temporal gyrus, temporal pole) to the inferior frontal and orbitofrontal cortex.
- It terminates in the frontal lobe's pars triangularis and pars orbitalis.
- Significant statistical differences in total UF volume and length were observed between hemispheres, suggesting leftward asymmetry.
Conclusions:
- The UF was divided into two parts, contrasting with previous three-part segmentation studies.
- This research enhances the understanding of the uncinate fasciculus's anatomy and connectivity.
