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Published on: February 21, 2012
Exploiting Copper Redox for (19)F Magnetic Resonance-Based Detection of Cellular Hypoxia
Da Xie1, Tyler L King1, Arnab Banerjee1
1Department of Chemistry, The University of Texas at Austin , 105 E. 24th St Stop A5300, Austin, Texas 78712, United States.
Abstract:
We report a pair of fluorinated, redox-active copper complexes for potential use as (19)F MRI contrast agents for detecting cellular hypoxia. Trifluorinated Cu(II) ATSM-F3 displays the appropriate redox potential for selective accumulation in hypoxic cells and a completely quenched (19)F NMR signal that is "turned on" following reduction to Cu(I). Incubation of cancer cells with CuATSM-F3 resulted in a selective detection of (19)F signal in cells grown under hypoxic conditions.

