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Related Concept Videos

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Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Obesity01:24

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Is Bariatric Surgery a Trigger Factor for Systemic Autoimmune Diseases?

Carlos A Cañas1, Andrés F Echeverri, Fabio E Ospina

  • 1From the *Unit of Rheumatology, †Instituto de Investigaciones Clínicas, and ‡Laboratory of Immunology, Fundación Valle del Lili, Cali, Colombia.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
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Summary

Bariatric surgery may be associated with the development of new autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis, in some patients. Further research is needed to understand this potential link in weight loss surgery patients.

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Area of Science:

  • Immunology
  • Endocrinology
  • Bariatric Surgery

Background:

  • Obesity is a proinflammatory state with altered cytokine profiles (e.g., elevated leptin, decreased adiponectin).
  • Bariatric surgery is effective for weight loss and comorbidity management in obese individuals.
  • Immune system changes following bariatric surgery are not fully understood.

Observation:

  • This case series describes four patients who developed systemic autoimmune diseases after bariatric surgery.
  • Patients were disease-free before surgery and developed autoimmune conditions within an average of 11.2 months post-operation.
  • Two women developed systemic lupus erythematosus (one with antiphospholipid syndrome), and two men developed rheumatoid arthritis.

Findings:

  • Bariatric surgery patients can develop new-onset autoimmune diseases.
  • The onset of autoimmune conditions occurred relatively soon after bariatric procedures.
  • Specific autoimmune conditions observed include systemic lupus erythematosus and rheumatoid arthritis.

Implications:

  • Clinicians should be aware of the potential association between bariatric surgery and the development of autoimmune diseases.
  • Establishing a causal relationship is complex due to multiple contributing factors (genetics, weight loss timeline, nutritional deficiencies).
  • Further investigation is warranted to elucidate the mechanisms linking bariatric surgery to autoimmune conditions.