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Updated: Mar 25, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis and neuroprotective activity of dictyoquinazol A and analogues
Yuvixza Lizarme1, Jonatan Wangsahardja1, Gabriella M Marcolin1
1School of Chemistry, UNSW Australia, Sydney NSW 2052, Australia.
Abstract:
A flexible and efficient synthesis of the neuroprotective alkaloid, dictyoquinazol A, is reported. Several structural analogues of the target molecule were produced, and the neuroprotective activity of this series of compounds was investigated using three different cell-based models of stroke. Several of the new compounds were found to have superior activity compared to the natural product. This work has established a new molecular scaffold that holds promise for a novel pharmaceutical treatment for stroke.
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