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Updated: Mar 25, 2026

Interfacing 3D Engineered Neuronal Cultures to Micro-Electrode Arrays: An Innovative In Vitro Experimental Model
Published on: October 18, 2015
Building functional networks of spiking model neurons
L F Abbott1,2, Brian DePasquale1, Raoul-Martin Memmesheimer1,3
1Department of Neuroscience, Columbia University College of Physicians and Surgeons, New York, New York, USA.
Abstract:
Most of the networks used by computer scientists and many of those studied by modelers in neuroscience represent unit activities as continuous variables. Neurons, however, communicate primarily through discontinuous spiking. We review methods for transferring our ability to construct interesting networks that perform relevant tasks from the artificial continuous domain to more realistic spiking network models. These methods raise a number of issues that warrant further theoretical and experimental study.
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