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A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
Published on: February 28, 2015
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DNA base-stacking assay utilizing catalytic hairpin assembly-induced gold nanoparticle aggregation for colorimetric
Chia-Chen Chang1, Chie-Pein Chen2, Chen-Yu Chen3
1Institute of Biomedical Engineering, National Taiwan University, Taipei 106, Taiwan, Republic of China. cwlinx@ntu.edu.tw.
Chemical Communications (Cambridge, England)
|February 25, 2016
Abstract:
A label-free and enzyme-free colorimetric sensing platform for the amplified detection of fibronectin was developed based on an ingenious combination of catalytic hairpin assembly and a base stacking hybridization-based gold nanoparticle aggregation strategy. The detection limit of 2.3 pM is at least one order of magnitude lower than that of established fibronectin biosensors.
