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Updated: Mar 25, 2026

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation

Published on: September 27, 2011

Photonic crystal micropost as a microarray platform.

Chih-Wei Chang, Cheng-Sheng Huang

|February 25, 2016

Summary

This summary is machine-generated.

A novel photonic crystal micropost (PCMP) substrate enhances microarray sensitivity. This substrate amplifies fluorescence signals up to 5.50x while reducing background noise, enabling detection of low-concentration analytes.

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High-Throughput Total Internal Reflection Fluorescence and Direct Stochastic Optical Reconstruction Microscopy Using a Photonic Chip

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Published on: November 16, 2019

Area of Science:

* Materials Science
* Nanotechnology
* Biomedical Engineering

Background:

* Microarray technology is crucial for high-throughput biological assays.
* Improving signal-to-noise ratio is essential for detecting low-abundance analytes.
* Existing substrates often suffer from high background noise, limiting sensitivity.

Purpose of the Study:

* To develop and demonstrate a photonic crystal micropost (PCMP) substrate for enhanced microarray applications.
* To investigate the signal enhancement capabilities of the PCMP substrate.
* To assess the impact of the PCMP substrate on background and noise levels.

Main Methods:

* Fabrication of a substrate comprising an array of microposts (MPs) topped with photonic crystals (PCs).
* Deposition of biomolecule-containing droplets onto the PCMP substrate, forming spots on the MPs.
* Excitation of the PC on resonance to enhance electric field intensity on the MP surfaces.

Main Results:

* Biomolecules selectively attach to the MPs, forming distinct spots.
* Fluorescence intensity is enhanced up to 5.50x due to localized electric field enhancement.
* Background and noise intensities remain minimal, preserving signal integrity.

Conclusions:

* The PCMP substrate significantly enhances spot intensity without increasing background noise.
* This technology improves the detection limit for low-concentration analytes in microarrays.
* PCMP substrates offer a promising platform for sensitive biological detection and diagnostics.