Chemokine gene variants in schizophrenia
Selcuk Dasdemir1, Cem Ismail Kucukali2, Elif Sinem Bireller1
1a Department of Molecular Medicine , Institute of Experimental Medicine, Istanbul University , Istanbul , Turkey ;
Nordic Journal of Psychiatry
|February 25, 2016
Summary
Chemokine gene variations, specifically CCR5-A55029G and CCR2-V64I, may be linked to schizophrenia development in the Turkish population. Further research is needed to confirm these genetic associations with schizophrenia risk.
Area of Science:
- Neuroscience
- Immunology
- Genetics
Background:
- Chemokines are crucial in neuroinflammatory diseases like Alzheimer's and Parkinson's.
- Inflammation is increasingly recognized as a factor in schizophrenia pathogenesis.
Purpose of the Study:
- To explore the association between specific chemokine gene polymorphisms and schizophrenia risk.
- Investigate MCP-1-A2518G, SDF-1-3'A, CCR5-delta32, CCR5-A55029G, CXCR4-C138T, and CCR2-V64I in the Turkish population.
Main Methods:
- Genotyping using PCR-RFLP.
- Analysis of 140 schizophrenia patients and 123 healthy controls.
- Statistical analysis including Bonferroni correction.
Main Results:
- Higher frequencies of CCR5-A55029G A and AG genotypes in patients.
- Significant association found for CCR2-V64I WT: CCR5-A55029G A and CCR2-V64I 64I: CCR5-A55029G A haplotypes.
- No significant association for other tested polymorphisms.
Conclusions:
- CCR5-A55029G polymorphisms may play a role in schizophrenia pathogenesis.
- Specific haplotypes involving CCR5 and CCR2 show a potential association with schizophrenia risk.
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