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Updated: Mar 25, 2026

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
Published on: July 11, 2015
Development of immune-diagnostic reagents to diagnose bovine tuberculosis in cattle
H Martin Vordermeier1, Gareth J Jones1, Bryce M Buddle2
1Animal and Plant Health Agency-Weybridge, Addlestone, Surrey, United Kingdom.
Abstract:
Bovine tuberculosis remains a major economic and animal welfare concern worldwide. As part of control strategies, cattle vaccination is being considered. This approach, used alongside conventional control policies, also requires the development of vaccine compatible diagnostic assays to distinguish infected from vaccinated animals (DIVA). In this review we discuss recent advances in DIVA development based on the detection of host cellular immune responses by blood testing or skin testing approaches.

