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Updated: Aug 19, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Preoperative maximal expiratory pressure is associated with duration of invasive mechanical ventilation after cardiac
Maurice Zanini1, Rosane Maria Nery2, Raquel Petry Buhler3
1Federal University of Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Brazil.
Objective:
To evaluate the association of maximal expiratory pressure (MEP), maximal inspiratory pressure (MIP), and peak expiratory flow (PEF) with total duration of invasive mechanical ventilation (IMV) in subjects undergoing cardiac surgery.
Background:
Prolonged IMV is associated with respiratory infections, prolonged hospitalization, and increased mortality. Pulmonary function tests can help predict postoperative outcomes after cardiac surgery.
Methods:
We recruited subjects admitted for cardiac surgery. All MIP, MEP, and PEF measurements were performed before surgery. Multivariable analysis was performed using a multiple linear regression model to control for possible confounders and test for association of MIP, MEP, and PEF with IMV duration.
Results:
Overall, 125 subjects were included in the study. Higher MEP was associated with reduced duration of IMV after adjustment for confounders (P = 0.015), but no such association was observed between MIP or PEF and IMV.
Conclusions:
In subjects undergoing elective cardiac surgery, preoperative MEP is associated with IMV duration.
Insights
Preoperative maximal expiratory pressure (MEP) predicts shorter invasive mechanical ventilation (IMV) duration in cardiac surgery patients. Higher MEP indicates a reduced need for prolonged IMV, aiding in better postoperative outcomes.
Area of Science:
- Cardiology
- Pulmonology
- Critical Care Medicine
Background:
- Prolonged invasive mechanical ventilation (IMV) increases risks of infections, extended hospital stays, and mortality.
- Pulmonary function tests (PFTs) show potential in predicting postoperative results in cardiac surgery patients.
Purpose of the Study:
- To investigate the relationship between maximal expiratory pressure (MEP), maximal inspiratory pressure (MIP), and peak expiratory flow (PEF) and the duration of IMV.
- To determine if PFTs can predict IMV duration in patients undergoing cardiac surgery.
Main Methods:
- Recruited patients undergoing cardiac surgery.
- Measured MEP, MIP, and PEF before surgery.
- Utilized multivariable linear regression to analyze the association between PFTs and IMV duration, controlling for confounders.
Main Results:
- 125 patients were included in the analysis.
- Higher MEP was significantly associated with a shorter duration of IMV (P=0.015) after adjusting for confounders.
- No significant association was found between MIP or PEF and IMV duration.
Conclusions:
- Preoperative MEP is a significant predictor of IMV duration in patients undergoing elective cardiac surgery.
- MEP may serve as a valuable tool for risk stratification and predicting postoperative ventilation requirements.
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