Related Experiment Video
Updated: Mar 25, 2026

08:31
Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models
Published on: December 17, 2021
3.5K
Sake Protein Supplementation Affects Exercise Performance and Biochemical Profiles in Power-Exercise-Trained Mice
Yi-Ming Chen1, Che-Li Lin2,3, Li Wei4
1Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan. 1021302@ntsu.edu.tw.
Nutrients
|February 25, 2016
Summary
This study shows that power exercise training (PET) improves mouse athletic performance and body composition. Supplementation with branched-chain amino acid-rich sake protein (SP) during PET enhanced anti-fatigue effects and improved biochemical markers.
Area of Science:
- Exercise physiology and sports nutrition.
- Biochemistry and performance enhancement.
Background:
- Sports nutrition supplementation is a significant global market.
- Understanding the effects of supplements on exercise performance is crucial.
Purpose of the Study:
- To design a power exercise training (PET) program in a mouse model.
- To evaluate the synergistic effect of branched-chain amino acid (BCAA)-rich sake protein (SP) supplementation during PET.
- To determine if SP enhances athletic performance and fatigue resistance.
Main Methods:
- Four-week PET program with and without SP supplementation (3.8 g/kg) in male ICR mice.
- Assessment of exercise performance via grip strength and exhaustive swimming time.
- Analysis of body composition and anti-fatigue activity through serum markers (lactate, ammonia, glucose, creatine kinase) and liver enzymes (AST, ALT).
Main Results:
- PET significantly increased grip strength and swimming time, while decreasing fat pad weight.
- PET led to increased levels of AST, ALT, creatinine, and uric acid.
- PET + SP supplementation significantly reduced post-exercise lactate, ammonia, and CK levels, and also lowered resting AST, ALT, creatinine, and uric acid.
Conclusions:
- The PET program effectively improved exercise performance and modulated body composition in mice.
- PET combined with SP supplementation demonstrated superior anti-fatigue activity and improved biochemical profiles.
- Sake protein (SP) may serve as an effective ergogenic aid for strength training programs.

