Related Experiment Video
Updated: Mar 25, 2026
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
FDG-PET/ceCT is useful to predict recurrence of Pseudomyxoma peritonei
Julien Dubreuil1,2, Francesco Giammarile3,4, Pascal Rousset5,6
1Nuclear Medicine and PET Unit, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, 165 Chemin du Grand Revoyet, 69495, Pierre-Bénite, France. julien.dubreuil@chu-lyon.fr.
Purpose:
Pseudomyxoma peritonei (PMP) is a rare peritoneal neoplasm originating from appendicular tumours. There is no consolidated data available in the literature about the precise role of [(18)F] fluorodesoxy-D-glucose Positron Emission Tomography / contrast enhanced Computed Tomography (FDG-PET/ceCT). The aim of this study was to evaluate the correlation between preoperative FDG-PET/ceCT (qualitative and semi-quantitative assessment) and progression free survival (PFS) of patients treated for PMP.
Methods:
All patients scheduled for PMP treatment by cytoreductive unicentric surgery, intraperitoneal chemotherapy (HIPEC), and who underwent a FDG-PET/ceCT between February 2008 and January 2014, were included. No previous treatment was performed (except biopsy or appendectomy). FDG-PET/ceCT was interpreted by two nuclear physicians in consensus. Positive FDG-PET/ceCT scans were further labelled in diffuse disease and poly/mono focal disease. SUVmax was measured based on post-operative reports. The Peritoneal Cancer Index (PCI) and Completeness of CytoReduction Score (CCR) were assessed after surgery.
Results:
Fifty-six patients were included in this study, with a mean age of 56-years-old and a mean follow-up of 29.3 months. SUVmax, with a cut-off at 2.02, was predictive for the PFS on multivariate analysis. No differences were observed between diffuse disease and focal disease on PFS for progression free survival, PCI, and SUVmax (p = 0.1). Post-operative CCR was not significantly correlated with SUVmax or FDG-PET/ceCT qualitative assessment.
Conclusion:
SUVmax on preoperative FDG-PET/ceCT was an independent predictive factor for PFS in PMP. Further studies are needed to explore if FDG-PET/ceCT could potentially predict post-operative CCR.
Insights
The maximum standardized uptake value (SUVmax) from preoperative [(18)F] fluorodesoxy-D-glucose Positron Emission Tomography / contrast enhanced Computed Tomography (FDG-PET/ceCT) can predict progression-free survival (PFS) in patients with pseudomyxoma peritonei (PMP). This imaging technique offers valuable prognostic information for PMP management.
Area of Science:
- Oncology
- Nuclear Medicine
- Surgical Oncology
Background:
- Pseudomyxoma peritonei (PMP) is a rare appendiceal neoplasm.
- Consolidated data on the role of [(18)F] fluorodesoxy-D-glucose Positron Emission Tomography / contrast enhanced Computed Tomography (FDG-PET/ceCT) in PMP is lacking.
- Accurate prognostic markers are crucial for PMP patient management.
Purpose of the Study:
- To evaluate the correlation between preoperative FDG-PET/ceCT (qualitative and semi-quantitative) and progression-free survival (PFS) in PMP patients.
- To assess the predictive value of FDG-PET/ceCT findings for PMP outcomes.
- To investigate potential correlations with other prognostic factors like Peritoneal Cancer Index (PCI) and Completeness of Cytoreduction (CCR).
Main Methods:
- Retrospective analysis of 56 PMP patients treated with cytoreductive surgery and HIPEC.
- Preoperative FDG-PET/ceCT scans were performed and interpreted by nuclear physicians.
- SUVmax was measured, and qualitative assessments (diffuse vs. focal disease) were made; post-operative PCI and CCR were recorded.
Main Results:
- SUVmax, with a cut-off of 2.02, was found to be an independent predictive factor for PFS on multivariate analysis.
- No significant differences in PFS, PCI, or SUVmax were observed between diffuse and focal disease patterns.
- Post-operative CCR did not significantly correlate with SUVmax or qualitative FDG-PET/ceCT findings.
Conclusions:
- Preoperative FDG-PET/ceCT SUVmax is a significant independent predictor of PFS in PMP.
- Further research is warranted to determine if FDG-PET/ceCT can predict post-operative CCR.
- FDG-PET/ceCT may aid in risk stratification and treatment planning for PMP.
More Related Videos
07:54Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
