Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

7.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.0K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.7K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.7K
Cancer Therapies02:49

Cancer Therapies

10.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.6K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

12.9K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
12.9K
Spongy Bone01:09

Spongy Bone

10.9K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
10.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased expression of autophagy-related proteins in keratocystic odontogenic tumours: its possible association with growth potential.

The British journal of oral & maxillofacial surgery·2014
Same author

The sabotage of the bacterial transcription machinery by a small bacteriophage protein.

Bacteriophage·2014
Same author

In vivo and in vitro evidence of the sex-dependent pharmacokinetics and disposition of G004, a potential hypoglycemic agent, in rats.

European journal of drug metabolism and pharmacokinetics·2014
Same author

Inositol pyrophosphates mediate the effects of aging on bone marrow mesenchymal stem cells by inhibiting Akt signaling.

Stem cell research & therapy·2014
Same author

Sequential release of autophagy inhibitor and chemotherapeutic drug with polymeric delivery system for oral squamous cell carcinoma therapy.

Molecular pharmaceutics·2014
Same author

Proteomic analysis of differentially expressed skin proteins in iRhom2(Uncv) mice.

BMB reports·2014
Same journal

Kitchen Table Discussions Uncover What Consumers Need in Recovery from a Cardiac Condition.

Heart, lung & circulation·2026
Same journal

Cardiovascular Drug Access in Australia and New Zealand: New PBS and PHARMAC Listings, 2023-2025.

Heart, lung & circulation·2026
Same journal

Initial 4-Year Experience with Microaxial Flow Pumps within a Tertiary Centre in Regional Australia.

Heart, lung & circulation·2026
Same journal

Health Care Workers' Preferences in the Delivery of Atrial Fibrillation Screening: A Systematic Review.

Heart, lung & circulation·2026
Same journal

Meta-Analysis of Randomised Controlled Trials on the Efficacy of Direct Oral Anticoagulants in Left Ventricular Thrombosis: An Updated Perspective.

Heart, lung & circulation·2026
Same journal

Letter to the Editor "Constructive Critique on CKM Implementation: Focusing on Non-Pharmacological Burden and Staging Utility" regarding: "Implementation Barriers to Evidence-Based Cardiovascular-Kidney-Metabolic Syndrome Management" by Davis et al. Heart Lung Circ. 2025;34:1060-1068.

Heart, lung & circulation·2026
See all related articles

Related Experiment Video

Updated: Mar 25, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

12.0K

Primary Cardiac Osteosarcoma.

Ji-Gang Wang1, Bing Liu2, Han Gao3

  • 1Department of Pathology, The Affiliated Hospital of Qingdao University, People's Republic of China; Department of Pathology, School of Basic Medical Sciences, Fudan University, People's Republic of China.

Heart, Lung & Circulation
|February 25, 2016
PubMed
Summary
This summary is machine-generated.

Primary cardiac osteosarcoma is a rare tumor. This study analyzed 53 cases, finding that sex, tumor size, and chemo-radiotherapy impact survival, offering diagnostic and treatment insights.

Keywords:
Cardiac tumourOsteosarcomaPrognosis

More Related Videos

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

4.4K
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.8K

Related Experiment Videos

Last Updated: Mar 25, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

12.0K
A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

4.4K
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.8K

Area of Science:

  • Cardiology
  • Oncology
  • Pathology

Background:

  • Primary cardiac osteosarcoma is an exceptionally rare malignancy.
  • No prior cohort studies have investigated this specific tumor type.
  • This study aims to elucidate the clinical characteristics and outcomes of primary cardiac osteosarcomas.

Purpose of the Study:

  • To characterize the clinical presentation of primary cardiac osteosarcoma.
  • To analyze prognostic factors influencing survival in these rare tumors.
  • To provide a basis for improved diagnosis and treatment strategies.

Main Methods:

  • A comprehensive literature review was conducted to identify relevant cases.
  • Data from 53 confirmed cases of primary cardiac osteosarcoma were collected and analyzed.
  • Patient demographics, clinical findings, and treatment modalities were systematically recorded.

Main Results:

  • The study included 25 males and 28 females, with ages ranging from 14 to 77 years (mean 43.6).
  • Clinical, imaging, and laboratory features were comparable to other primary cardiac tumors.
  • Overall survival was significantly influenced by patient sex, tumor size, and the use of chemo-radiotherapy.

Conclusions:

  • This study provides valuable insights into the clinical behavior of primary cardiac osteosarcoma.
  • Findings can aid clinicians in the diagnosis and management of this rare condition.
  • Further research may refine treatment protocols for improved patient outcomes.