Related Experiment Video

Updated: Mar 25, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

14.0K

Central Venous Catheters and Bloodstream Infection During Induction Therapy in Children With Acute Lymphoblastic

Kristin Bergmann1, Henrik Hasle, Peter Asdahl

  • 1*Department of Pediatrics, Aarhus University Hospital, Aarhus †Department of Pediatrics, Odense University Hospital, Odense ‡Department of Pediatrics, Aalborg University Hospital, Aalborg, Denmark.

Journal of Pediatric Hematology/Oncology
|February 25, 2016
PubMed

Insights

The type of central venous catheter (CVC) used in children with acute lymphoblastic leukemia (ALL) during induction therapy did not impact the risk of bloodstream infection (BSI). This finding applies to both nontunneled and tunneled CVCs.

Area of Science:

  • Pediatric Oncology
  • Infectious Diseases
  • Hematology

Background:

  • Central venous catheters (CVCs) are essential for administering chemotherapy during induction therapy for acute lymphoblastic leukemia (ALL).
  • Bloodstream infections (BSIs) are a significant complication in pediatric ALL patients, potentially delaying treatment.
  • Understanding the influence of CVC type on BSI risk is crucial for optimizing patient care.

Purpose of the Study:

  • To evaluate the association between CVC type and the risk of first-time bloodstream infection (BSI) in pediatric ALL patients undergoing induction therapy.
  • To compare BSI incidence between children with nontunneled CVCs and those with tunneled CVCs with external lines (TE).

Main Methods:

  • Retrospective analysis of 136 newly diagnosed pediatric ALL patients treated between 2008 and 2014 at three Danish centers.
  • Patients were monitored from CVC placement until BSI, CVC removal, death, or day 28.
  • Cumulative incidence of BSI was calculated and compared between CVC groups.

Main Results:

  • The 28-day cumulative incidence of BSI was comparable between nontunneled CVC (28%) and TE CVC (33%) groups.
  • Gram-positive infections were the most common type of BSI (67%).
  • Subgroup analyses indicated higher gram-negative isolates with TE CVCs and lower BSI rates in older patients (>9 years) with TE CVCs and T-ALL patients.

Conclusions:

  • The type of central venous catheter (CVC) inserted at diagnosis does not significantly influence the risk of bloodstream infection (BSI) in pediatric patients with acute lymphoblastic leukemia (ALL) during induction therapy.
  • While overall BSI risk appears similar, specific infection patterns (gram-negative) and patient subgroups (older patients, T-ALL) may show variations based on CVC type.
  • Further research may explore other factors influencing BSI risk beyond CVC type in this vulnerable population.

More Related Videos

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

829
Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor CAR T Cell Infusions in Mice05:22

Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor CAR T Cell Infusions in Mice

Published on: February 24, 2023

4.4K

Related Concept Videos

Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
561
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.3K
Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
1.5K