[Available fluoride from various drugs after oral application].

Area of Science:

• Pharmacokinetics and Biopharmaceutics
• Dental Public Health
• Biochemistry

Context:

• Understanding fluoride bioavailability is crucial for effective caries prevention strategies.
• Assessing different oral fluoride formulations is essential for optimizing therapeutic outcomes.
• Human plasma and parotid saliva are key biological matrices for evaluating systemic fluoride absorption.

Purpose:

• To determine and compare the plasma and parotid saliva fluoride profiles following oral administration of six different fluoride preparations.
• To evaluate the bioavailability and absorption kinetics of various fluoride delivery systems.
• To identify fluoride preparations with optimal bioavailability for potential pre-eruptive caries prophylaxis.

Summary:

• Fluoride concentrations in human plasma and parotid saliva were measured for 24 hours after oral intake of six different preparations.
• Sodium fluoride (NaF) administration resulted in the highest observed fluoride concentrations in both plasma and saliva.
• Fluoride levels returned to baseline approximately 8 hours post-administration, with parotid saliva values slightly lower than plasma but exhibiting parallel concentration profiles.

Impact:

• The findings indicate that NaF exhibits favorable bioavailability, supporting its use in pre-eruptive caries-prophylactic strategies.
• This research provides valuable data for the development and selection of effective fluoride-based dental health interventions.
• Optimized fluoride delivery systems can enhance pre-eruptive tooth enamel mineralization, leading to improved caries resistance.