Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

8.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.8K
The Thyroid Gland01:23

The Thyroid Gland

8.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
8.6K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

6.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
6.5K
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

66
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
66

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combination Radiopharmaceutical Therapy and Radiotherapy for Thyroid Cancer: Dosimetry-Driven Precision Medicine.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025
Same author

Genetic modification of the AJCC classification of papillary thyroid cancer: an international, multicentre, retrospective cohort study.

The Lancet. Oncology·2025
Same author

Combined Afirma Genomic Sequencing Classifier and TERT promoter mutation detection in molecular assessment of Bethesda III-VI thyroid nodules.

Cancer cytopathology·2023
Same author

Preoperative Identification of Medullary Thyroid Carcinoma (MTC): Clinical Validation of the Afirma MTC RNA-Sequencing Classifier.

Thyroid : official journal of the American Thyroid Association·2022
Same author

Pre-existing Thyroid Autoimmunity and Risk of Papillary Thyroid Cancer: A Nested Case-Control Study of US Active-Duty Personnel.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2022
Same author

Real-time quantitation of thyroidal radioiodine uptake in thyroid disease with monitoring by a collar detection device.

Scientific reports·2021

Related Experiment Video

Updated: Mar 25, 2026

A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery
04:42

A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery

Published on: February 17, 2023

1.9K

Precision Medicine Comes to Thyroidology.

Paul W Ladenson1

  • 1Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0003.

The Journal of Clinical Endocrinology and Metabolism
|February 25, 2016
PubMed
Summary

Thyroid disease management requires individualized care due to its wide severity spectrum. Advances in diagnostics and treatments are paving the way for precision medicine in endocrinology.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Genetics

Background:

  • Thyroid diseases present a broad spectrum of severity, from subclinical conditions to life-threatening emergencies and cancers.
  • Individualized patient management is crucial for effective treatment of diverse thyroid pathologies.
  • Current understanding of thyroid pathophysiology is expanding rapidly.

Purpose of the Study:

  • To highlight the necessity of personalized approaches in managing thyroid disorders.
  • To emphasize the role of emerging technologies in advancing thyroid disease care.
  • To position the field of thyroidology within the context of precision medicine.

Main Methods:

  • Review of current literature on thyroid disease pathophysiology.
  • Analysis of advancements in diagnostic technologies for thyroid conditions.

More Related Videos

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

1.2K
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

1.1K

Related Experiment Videos

Last Updated: Mar 25, 2026

A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery
04:42

A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery

Published on: February 17, 2023

1.9K
Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

1.2K
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

1.1K
  • Evaluation of new prognostic and therapeutic strategies in endocrinology.
  • Main Results:

    • The wide range of thyroid disease severity necessitates tailored clinical strategies.
    • Technological progress is enhancing diagnostic accuracy and therapeutic efficacy.
    • Precision medicine approaches are becoming increasingly relevant for thyroid patient care.

    Conclusions:

    • Individualized management remains paramount in treating the spectrum of thyroid diseases.
    • Advances in technology and pathophysiology knowledge are driving the adoption of precision medicine in endocrinology.
    • The future of thyroidology lies in integrating personalized diagnostics and therapeutics.