Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Retrovirus Life Cycles01:10

Retrovirus Life Cycles

50.5K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
50.5K
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

4.6K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
4.6K
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

1.6K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.6K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

1.2K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.2K
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

4.8K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.8K
Preventive Healthcare Services01:30

Preventive Healthcare Services

2.3K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of hematopoietic stem cell-derived microglia-like cells in nonhuman primates.

Blood advances·2026
Same author

Menstruation is associated with cyclical granulysin peaks in vaginal secretions despite stable expression by cervicovaginal immune cells.

bioRxiv : the preprint server for biology·2026
Same author

Projected public health benefits of a hypothetical HSV-1 vaccine in the United States: A mathematical modeling analysis.

Science advances·2026
Same author

[211At]Astatine-Based Conditioning with a Humanized CD45 Antibody for Autologous Hematopoietic Stem Cell Gene Therapy.

Blood·2026
Same author

<i>In vivo</i> HSC gene therapy enables sustained eCD4-Ig expression for SIV prevention.

Molecular therapy. Advances·2026
Same author

Smac mimetic combined with eCD4-Ig reverses latency without reducing SHIV reservoirs in rhesus macaques.

The Journal of clinical investigation·2026

Related Experiment Video

Updated: Mar 25, 2026

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

3.0K

A curative regimen would decrease HIV prevalence but not HIV incidence unless targeted to an ART-naïve population.

Dobromir T Dimitrov1,2, Hans-Peter Kiem3,4, Keith R Jerome1,5

  • 1Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Scientific Reports
|February 25, 2016
PubMed
Summary
This summary is machine-generated.

Implementing HIV cure strategies could reduce HIV prevalence. However, significant reductions in new infections require targeting patients not yet on antiretroviral treatment (ART).

More Related Videos

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

18.5K
New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
09:27

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

Published on: May 30, 2013

11.7K

Related Experiment Videos

Last Updated: Mar 25, 2026

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

3.0K
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

18.5K
New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
09:27

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

Published on: May 30, 2013

11.7K

Area of Science:

  • Epidemiology
  • Mathematical Modeling
  • Virology

Background:

  • Current HIV cure strategies aim to eliminate latent provirus or prevent viral replication, progression to AIDS, and transmission.
  • The epidemiological impact of implementing HIV cure programs has not been extensively evaluated.

Purpose of the Study:

  • To evaluate the independent and synergistic impact of antiretroviral treatment (ART), HIV prevention interventions, and cure strategies on HIV prevalence and incidence using a mathematical model.
  • To assess the potential for HIV epidemic elimination by calculating the basic reproduction number.

Main Methods:

  • Development of a mathematical model simulating heterosexual HIV transmission.
  • Exploration of scenarios with and without the assumption that patients in cure programs must be on ART.
  • Calculation of the basic reproduction number to determine epidemic elimination potential.

Main Results:

  • HIV cure strategies showed limited impact on incidence when only ART-eligible patients were enrolled.
  • Significant reductions in HIV incidence were observed when ART-untreated patients were directly enrolled in cure programs.
  • Concurrent HIV prevention programs moderately reduced the proportion of treated or cured patients needed for epidemic elimination.

Conclusions:

  • Widespread implementation of HIV cure is projected to decrease HIV prevalence across all simulated scenarios.
  • Lowering new HIV infections through cure strategies is contingent on targeting ART-untreated individuals.
  • Enhanced efforts to identify and reach untreated HIV patients will be crucial for the success of future HIV cure initiatives.